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Bipolar I disorder

MedGen UID:
678499
•Concept ID:
C0853193
•
Mental or Behavioral Dysfunction
Synonyms: Bipolar 1 disorder; bipolar 1 disorder; bipolar I disorder
SNOMED CT: Bipolar I disorder (371596008); Bipolar 1 disorder (371596008)
 
Monarch Initiative: MONDO:0001866

Definition

A bipolar disorder that is characterized by at least one manic or mixed episode. [from MONDO]

Professional guidelines

PubMed

Bipolar Disorders: Evaluation and Treatment.
Marzani G, Price Neff A
Am Fam Physician 2021 Feb 15;103(4):227-239. PMID: 33587568
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.
Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, Sharma V, Goldstein BI, Rej S, Beaulieu S, Alda M, MacQueen G, Milev RV, Ravindran A, O'Donovan C, McIntosh D, Lam RW, Vazquez G, Kapczinski F, McIntyre RS, Kozicky J, Kanba S, Lafer B, Suppes T, Calabrese JR, Vieta E, Malhi G, Post RM, Berk M
Bipolar Disord 2018 Mar;20(2):97-170. Epub 2018 Mar 14 doi: 10.1111/bdi.12609. PMID: 29536616Free PMC Article
The Diagnosis and Management of Bipolar I and II Disorders: Clinical Practice Update.
Bobo WV
Mayo Clin Proc 2017 Oct;92(10):1532-1551. Epub 2017 Sep 6 doi: 10.1016/j.mayocp.2017.06.022. PMID: 28888714

Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Therapy

Safety and Efficacy of Aripiprazole 2-Month Ready-to-Use 960 mg: Secondary Analysis of Outcomes in Adult Patients With Schizophrenia in a Randomized, Open-label, Parallel-Arm, Pivotal Study.
Citrome L, Such P, Yildirim M, Madera-McDonough J, Beckham C, Zhang Z, Larsen F, Harlin M
J Clin Psychiatry 2023 Sep 4;84(5) doi: 10.4088/JCP.23m14873. PMID: 37672016
Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression.
Yatham LN, Arumugham SS, Kesavan M, Ramachandran K, Murthy NS, Saraf G, Ouyang Y, Bond DJ, Schaffer A, Ravindran A, Ravindran N, Frey BN, Daigneault A, Beaulieu S, Lam RW, Kondapuram N, Reddy MS, Bhandary RP, Ashok MV, Ha K, Ahn YM, Milev R, Wong H, Reddy YCJ; BEAM-BD Trial Group
N Engl J Med 2023 Aug 3;389(5):430-440. doi: 10.1056/NEJMoa2300184. PMID: 37530824
A Randomized, Open-Label, Multiple-Dose, Parallel-Arm, Pivotal Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Aripiprazole 2-Month Long-Acting Injectable in Adults With Schizophrenia or Bipolar I Disorder.
Harlin M, Yildirim M, Such P, Madera-McDonough J, Jan M, Jin N, Watkin S, Larsen F
CNS Drugs 2023 Apr;37(4):337-350. Epub 2023 Mar 24 doi: 10.1007/s40263-023-00996-8. PMID: 36961650Free PMC Article
A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.
Patino LR, Klein CC, Strawn JR, Blom TJ, Tallman MJ, Adler CM, Welge JA, DelBello MP
J Child Adolesc Psychopharmacol 2021 Sep;31(7):485-493. Epub 2021 Sep 14 doi: 10.1089/cap.2021.0039. PMID: 34520250Free PMC Article
Asenapine.
Weber J, McCormack PL
CNS Drugs 2009 Sep;23(9):781-92. doi: 10.2165/11200860-000000000-00000. PMID: 19689168

Prognosis

Bipolar Disorders: Evaluation and Treatment.
Marzani G, Price Neff A
Am Fam Physician 2021 Feb 15;103(4):227-239. PMID: 33587568
Psychosis, Mania and Criminal Recidivism: Associations and Implications for Prevention.
Lamberti JS, Katsetos V, Jacobowitz DB, Weisman RL
Harv Rev Psychiatry 2020 May/Jun;28(3):179-202. doi: 10.1097/HRP.0000000000000251. PMID: 32251070
An overview of pharmacotherapy for bipolar I disorder.
Morsel AM, Morrens M, Sabbe B
Expert Opin Pharmacother 2018 Feb;19(3):203-222. Epub 2018 Jan 23 doi: 10.1080/14656566.2018.1426746. PMID: 29361880
Biological dysrhythm in remitted bipolar I disorder.
Iyer A, Palaniappan P
Asian J Psychiatr 2017 Dec;30:218-224. Epub 2017 May 17 doi: 10.1016/j.ajp.2017.05.012. PMID: 28559123
Emotion in bipolar I disorder: Implications for functional and symptom outcomes.
Johnson SL, Tharp JA, Peckham AD, McMaster KJ
J Abnorm Psychol 2016 Jan;125(1):40-52. Epub 2015 Oct 19 doi: 10.1037/abn0000116. PMID: 26480234Free PMC Article

Clinical prediction guides

A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.
Patino LR, Klein CC, Strawn JR, Blom TJ, Tallman MJ, Adler CM, Welge JA, DelBello MP
J Child Adolesc Psychopharmacol 2021 Sep;31(7):485-493. Epub 2021 Sep 14 doi: 10.1089/cap.2021.0039. PMID: 34520250Free PMC Article
Melatonin Receptor Gene Polymorphism in Bipolar-I Disorder.
Mulayim E, Karababa İF, Akbaş H, Bayazıt H, Selek S
Arch Med Res 2021 Jul;52(5):523-528. Epub 2021 Feb 2 doi: 10.1016/j.arcmed.2021.01.002. PMID: 33546869
Diagnosing bipolar II disorder: some personal perspectives.
Parker G
Australas Psychiatry 2015 Apr;23(2):112-5. Epub 2015 Feb 4 doi: 10.1177/1039856214568218. PMID: 25653300
Asenapine.
Weber J, McCormack PL
CNS Drugs 2009 Sep;23(9):781-92. doi: 10.2165/11200860-000000000-00000. PMID: 19689168
Bipolar disorder and aggression.
Látalová K
Int J Clin Pract 2009 Jun;63(6):889-99. doi: 10.1111/j.1742-1241.2009.02001.x. PMID: 19490199

Recent systematic reviews

Comparing suicide completion rates in bipolar I versus bipolar II disorder: A systematic review and meta-analysis.
Dev DA, Le GH, Kwan ATH, Wong S, Arulmozhi A, Ceban F, Teopiz KM, Meshkat S, Rosenblat JD, Guillen-Burgos HF, Rhee TG, Ho RC, Cao B, d'Andrea G, Sundberg I, McIntyre RS
J Affect Disord 2024 Sep 15;361:480-488. Epub 2024 Jun 18 doi: 10.1016/j.jad.2024.06.045. PMID: 38901691
Significant predictors for olanzapine pharmacokinetics: a systematic review of population pharmacokinetic studies.
Mao JH, Han L, Liu XQ, Jiao Z
Expert Rev Clin Pharmacol 2023 Jan-Jun;16(6):575-588. Epub 2023 Jun 7 doi: 10.1080/17512433.2023.2219055. PMID: 37231707
Longitudinal grey matter changes following first episode mania in bipolar I disorder: A systematic review.
Cahn AJ, Keramatian K, Frysch C, Yatham LN, Chakrabarty T
J Affect Disord 2021 Aug 1;291:198-208. Epub 2021 May 7 doi: 10.1016/j.jad.2021.04.051. PMID: 34049189
Comparative efficacy and tolerability of pharmacological treatments for the treatment of acute bipolar depression: A systematic review and network meta-analysis.
Bahji A, Ermacora D, Stephenson C, Hawken ER, Vazquez G
J Affect Disord 2020 May 15;269:154-184. Epub 2020 Mar 20 doi: 10.1016/j.jad.2020.03.030. PMID: 32339131
Migraine headache and bipolar disorder comorbidity: A systematic review of the literature and clinical implications.
Leo RJ, Singh J
Scand J Pain 2016 Apr;11:136-145. Epub 2016 Feb 23 doi: 10.1016/j.sjpain.2015.12.002. PMID: 28850455

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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